What does 21 CFR part 582 cover?

21 CFR Part 582: Substances Generally Recognized as Safe

Part 582 of title 21 runs to 243 sections across 8 subparts, and sits in subchapter E, Animal Drugs, Feeds, and Related Products. Every section is reproduced in full and is current to 2026-09-10.

Sections: 243
Subparts: 8
Words of regulation: 7,264
Current to: 2026-09-10

Subpart A: General Provisions

Subpart B: General Purpose Food Additives

Subpart C: Anticaking Agents

Subpart D: Chemical Preservatives

Subpart E: Emulsifying Agents

Subpart F: Nutrients and/or Dietary Supplements 1

Subpart G: Sequestrants 2

Subpart H: Stabilizers

Read 21 CFR part 582 at the eCFR · All of 21 CFR for food safety

Questions

What does 21 CFR part 582 cover?: 21 CFR part 582 is Substances Generally Recognized as Safe. It runs to 243 sections across 8 subparts and sits in subchapter E of chapter I, Animal Drugs, Feeds, and Related Products.

Every section of part 582 is a clause somebody has to produce evidence for at their next audit. Krolda maps supplier documents to the clause they satisfy in FSSC 22000, IFS Food and 21 CFR 117, and routes the corrective action when the evidence is missing.

Early access

Recall records come from the openFDA food enforcement API, published by the U.S. Food and Drug Administration in the public domain. Krolda adds the hazard classification and the clause mapping; neither is an FDA determination. Always check the FDA notice before acting on a recall.