21 CFR Part 189: Substances Prohibited from Use in Human Food
Part 189 of title 21 runs to 21 sections across 4 subparts, and sits in subchapter B, Food for Human Consumption. Every section is reproduced in full and is current to 2026-09-10.
- Sections
- 21
- Subparts
- 4
- Words of regulation
- 3,753
- Current to
- 2026-09-10
Subpart A: General Provisions
Subpart B: Prohibited Cattle Materials
Subpart C: Substances Generally Prohibited From Direct Addition or Use as Human Food
- 189.110 Calamus and its derivatives3
- 189.113 Cinnamyl anthranilate2
- 189.120 Cobaltous salts and its derivatives2
- 189.130 Coumarin3
- 189.135 Cyclamate and its derivatives3
- 189.140 Diethylpyrocarbonate (DEPC)2
- 189.145 Dulcin3
- 189.155 Monochloroacetic acid3
- 189.165 Nordihydroguaiaretic acid (NDGA)3
- 189.175 P-40003
- 189.180 Safrole3
- 189.190 Thiourea3
- 189.191 Chlorofluorocarbon propellants1
Subpart D: Substances Prohibited From Indirect Addition to Human Food Through Food-Contact Surfaces
Read 21 CFR part 189 at the eCFR · All of 21 CFR for food safety
Questions
- What does 21 CFR part 189 cover?
- 21 CFR part 189 is Substances Prohibited from Use in Human Food. It runs to 21 sections across 4 subparts and sits in subchapter B of chapter I, Food for Human Consumption.
Every section of part 189 is a clause somebody has to produce evidence for at their next audit. Krolda maps supplier documents to the clause they satisfy in FSSC 22000, IFS Food and 21 CFR 117, and routes the corrective action when the evidence is missing.
Early accessRecall records come from the openFDA food enforcement API, published by the U.S. Food and Drug Administration in the public domain. Krolda adds the hazard classification and the clause mapping; neither is an FDA determination. Always check the FDA notice before acting on a recall.