21 CFR Part 181: Prior-Sanctioned Food Ingredients
Part 181 of title 21 runs to 14 sections across 2 subparts, and sits in subchapter B, Food for Human Consumption. Every section is reproduced in full and is current to 2026-09-10.
- Sections
- 14
- Subparts
- 2
- Words of regulation
- 1,512
- Current to
- 2026-09-10
Subpart A: General Provisions
Subpart B: Specific Prior-Sanctioned Food Ingredients
- 181.22 Certain substances employed in the manufacture of food-packaging materials1
- 181.23 Antimycotics1
- 181.24 Antioxidants1
- 181.25 Driers1
- 181.26 Drying oils as components of finished resins1
- 181.27 Plasticizers1
- 181.28 Release agents1
- 181.29 Stabilizers1
- 181.30 Substances used in the manufacture of paper and paperboard products used in food packaging2
- 181.32 Acrylonitrile copolymers and resins17
- 181.33 Sodium nitrate and potassium nitrate1
- 181.34 Sodium nitrite and potassium nitrite1
Read 21 CFR part 181 at the eCFR · All of 21 CFR for food safety
Questions
- What does 21 CFR part 181 cover?
- 21 CFR part 181 is Prior-Sanctioned Food Ingredients. It runs to 14 sections across 2 subparts and sits in subchapter B of chapter I, Food for Human Consumption.
Every section of part 181 is a clause somebody has to produce evidence for at their next audit. Krolda maps supplier documents to the clause they satisfy in FSSC 22000, IFS Food and 21 CFR 117, and routes the corrective action when the evidence is missing.
Early accessRecall records come from the openFDA food enforcement API, published by the U.S. Food and Drug Administration in the public domain. Krolda adds the hazard classification and the clause mapping; neither is an FDA determination. Always check the FDA notice before acting on a recall.