What does 21 CFR part 121 cover?

21 CFR part 121 is Mitigation Strategies to Protect Food Against Intentional Adulteration. It runs to 20 sections across 4 subparts and sits in subchapter B of chapter I, Food for Human Consumption.

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21 CFR Part 121: Mitigation Strategies to Protect Food Against Intentional Adulteration

Part 121 of title 21 runs to 20 sections across 4 subparts, and sits in subchapter B, Food for Human Consumption. Every section is reproduced in full and is current to 2026-09-10.

Sections: 20
Subparts: 4
Words of regulation: 3,978
Current to: 2026-09-10

Subpart A: General Provisions

Subpart C: Food Defense Measures

Subpart D: Requirements Applying to Records That Must Be Established and Maintained

Subpart E: Compliance

121.401 Compliance2

Read 21 CFR part 121 at the eCFR · All of 21 CFR for food safety

Questions

What does 21 CFR part 121 cover?: 21 CFR part 121 is Mitigation Strategies to Protect Food Against Intentional Adulteration. It runs to 20 sections across 4 subparts and sits in subchapter B of chapter I, Food for Human Consumption.

Every section of part 121 is a clause somebody has to produce evidence for at their next audit. Krolda maps supplier documents to the clause they satisfy in FSSC 22000, IFS Food and 21 CFR 117, and routes the corrective action when the evidence is missing.

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Recall records come from the openFDA food enforcement API, published by the U.S. Food and Drug Administration in the public domain. Krolda adds the hazard classification and the clause mapping; neither is an FDA determination. Always check the FDA notice before acting on a recall.